R&D PIPELINE

RESEARCH
IND/ENABLING
PHASE 1
PHASE 2
PHASE 3
OM002 (2’FL)
Irritable Bowel Syndrome - Constipation
Irritable Bowel Syndrome - Diarrhea
Frailty
OM001 (3’SL)
Rheumatoid & Juvenile Idiopathic Arthritis
Atopic Dermatitis
Autism Spectrum Disorder
OM003 (6’SL)
Autism Spectrum Disorder
Visceral Pain

OM002

The prevalence of IBS is approximately 5% of the United States population. IBS is a chronic functional gastrointestinal disorder characterized by abdominal pain and discomfort associated with altered bowel habits. Patients often experience additional symptoms such as bloating, sensation of incomplete evacuation, and straining. The symptoms of IBS not only adversely affect a person’s health-related quality of life, or QOL, but also place a significant financial burden on society because of reduced work productivity and a significant increase (over approximately 50%) in the use of health-related resources. IBS comprises three distinct subtypes, which are categorized based on predominant bowel symptoms (i.e., constipation, diarrhea, or mixed).

OM001

oJIA is the most common subtype of juvenile idiopathic arthritis, or JIA, among patients of European descent, making up about 40-50% of children with JIA from independent, third party published cohorts of patients as of August 2021. Polyarticular JIA, or pJIA, is the second most common subtype of JIA where the primary differentiation from oJIA is the number of joints affected within first six months of onset. For oJIA, the number of joints affected is four or less, whereas in polyarticular JIA, which is typically more severe than oJIA, the patients present with five or more affected joints.

AD is the most common type of eczema, affecting more than 9.6 million children and about 16.5 million adults in the United States as of December 2021. Like other immune mediated conditions, the prevalence of childhood AD has steadily increased from 8% to ~12% in decades to 2017. It is a chronic condition that can come and go for years or throughout life and can overlap with other types of eczema. Atopic dermatitis typically begins in childhood, usually in the first six months of a baby’s life. Even though it’s a common form of eczema, it’s also severe and long-lasting.

ASD is a developmental disability that can cause significant social, communication and behavioral challenges. In 2020, the U.S. Centers for Disease Control and Prevention reported that approximately 1 in 54 children in the United States is diagnosed with a form of ASD. People with ASD may communicate, interact, behave, and learn in ways that are different from most other people. The learning, thinking, and problem-solving abilities of people with ASD can range from gifted to severely challenged. Some people with ASD need a lot of help in their daily lives; others need less. ASD can sometimes be detected at 18 months or younger. By age two, a diagnosis by an experienced professional can be considered very reliable. However, many children do not receive a final diagnosis until much older.

OM003

ASD is a developmental disability that can cause significant social, communication and behavioral challenges. In 2020, the U.S. Centers for Disease Control and Prevention reported that approximately 1 in 54 children in the United States is diagnosed with a form of ASD. People with ASD may communicate, interact, behave, and learn in ways that are different from most other people. The learning, thinking, and problem-solving abilities of people with ASD can range from gifted to severely challenged. Some people with ASD need a lot of help in their daily lives; others need less. ASD can sometimes be detected at 18 months or younger. By age two, a diagnosis by an experienced professional can be considered very reliable. However, many children do not receive a final diagnosis until much older.